xQuest is a novel search engine for cross-linked peptides from complex samples. It was presented at the ASMS 2007, and was published in Nature Methods. xQuest works with small and large protein databases and features flexible fragment ion assignment, advanced scoring, and interactive evaluation tools.

Installable version of xQuest is availaible from here

xQuest was developed by Oliver Rinner at the IMSB at the ETH Zurich

start xQuest for cross-linker search with MS/MS information

start xBobcat mass-matching without MS/MS information

xQuest, a new program designed for cross-linking in a very complex mixture sample, is probably the most sophisticated {cross-link search} software developed so far... Y.J. Lee, Mol. BioSyst., 2008, 4, 816823


October 2010, xQuest is in Nature: Pang, S.S., et al., The structural basis for autonomous dimerization of the pre-T-cell antigen receptor. Nature. 467(7317): p. 844-848.